Hi,
Alexis Gambis, a student having spent his Internship with us at Pasteur, has just finished his project : Interaction between the User and Heijne's membrane topology prediction algorithm Toppred
We thought that the mixin technique could be useful to enhance the interaction between user and algorithm by the mean of supplemental user input taken into account without modifying the algorithm.
His results are summarized here: http://www-alt.pasteur.fr/~letondal/biok/usermixin.html